National Suicide Prevention Lifeline. The National Suicide Prevention Lifeline is a national, federally funded network of local crisis centers providing suicide prevention and intervention services through a toll-free telephone number: 1-800-273-TALK (8255) (Spanish-speaking callers: 1-888-628-9454). Its mission is to provide immediate assistance to individuals in suicidal crisis by connecting them to the nearest available crisis center in their area. For more information, visit www.suicidepreventionlifeline.org.